Dr. Jan Olson By: Dr. Jan Olson
HESI A2 Anatomy and Physiology Practice Test

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If you are a nursing student who is required to take the HESI exam, you may want to concentrate on taking a HESI anatomy and physiology practice test.

Breaking each part of the test into sections to study may help you feel like you have a deeper understanding of each topic.

In the A&P section of the exam, you will be asked questions relating to the body and how it functions. In this article, we will discuss the HESI A2 anatomy and physiology section in detail and give you ways to improve your scores.

Summary: Utilize our HESI anatomy and physiology practice test below to see how you would do if you took the HESI A&P exam today. For help with other sections, use our HESI exam practice materials.

Practice tests are a great way to study for any kind of test as you will be familiarizing yourself with the questions that you will be seeing on the actual test. Most of the time, they are questions from older versions of the test.

The HESI A2 practice test anatomy and physiology section is especially helpful to get you to focus on the anatomy and physiology section of the test without overwhelming you with other information. Take a practice exam below.

  1. A&P Practice Test 1
  2. A&P Practice Test 2
  3. A&P Practice Test 3

Make sure you are utilizing the answer explanations at the end of each A&P HESI practice test. These answer explanations will help you better understand important concepts. For help with other sections, use our free HESI A2 practice test.

Our Recommended HESI Prep Course

If you are serious about passing your HESI exam, try our recommended HESI Prep Course

Prepare Now

Of all the sections of the HESI A2 test, the anatomy and physiology section may be the one that covers the most material. With more than ten topics covered, this section can certainly be overwhelming even to those who think they know anatomy and physiology well.

The exam in totality covers ten main topics of standard learning— Reading Comprehension, Vocabulary and General Knowledge, Grammar, Math, Biology, Anatomy and Physiology, Chemistry, and Physics, Personality, and Learning Style —and each can be equally difficult if not reviewed properly.

In the following sections, we will discuss the subjects covered in the anatomy and physiology portion of the exam and provide you with the best methods of study for the HESI anatomy and physiology test.

How Many A&P Questions are on the HESI A2 Exam?

You are allotted 25 minutes to complete the 30 questions in the anatomy and physiology section of the HESI A2. Of those 30 questions, only 25 are scored – you will not know which questions are unscored.

You will have a little less than 1 minute to answer each question. However, there will likely be questions that you know the answer to immediately, so you will likely have more time than you think to take this section.

Since the sections are timed, we highly recommend timing yourself if you take a HESI A2 practice test anatomy and physiology section. If you do so, you will learn where you need to improve and discover how quickly you need to answer.

As for passing, most programs accept 70-80% as a passing score. Unlike other sections that have more questions, you will need to get almost all of the questions right to pass. It takes a minimum of 18 questions answered correctly to pass, so this section needs to be taken seriously.

What Kinds of Questions are on the HESI Anatomy and Physiology Test?

There are numerous subjects covered in the HESI A2 anatomy and physiology test. We will describe each section in detail to give you a better idea of what you can expect to see and study.

Planes and Terms of Direction

You will see sections that ask you to describe body orientation, so it is important to know the three planes and ten terms of orientation. Here are the ones you need to know:


  • Sagittal plane – splits the body into left and right sides from head to toe
  • Coronal/Frontal plane – splits the body to back and front from head to toe
  • Transverse/Horizontal plane – splits the body into top and bottom at the waist

Terms of Direction

  • Superior - above
  • Inferior - below
  • Anterior/Ventral - towards or in front of the body
  • Posterior/Dorsal - behind, towards the backside of the body
  • Medial - closer to the midline of the body
  • Lateral - farther away from the midline of the body
  • Proximal - closer or toward the body trunk/chest/center of the body
  • Distal - farther and distancing away from the body trunk/chest/center of the body
  • Superficial - closer to the outer layer and surface of the body
  • Deep - away from the surface of the body

Skeletal System

The skeletal system will cover all things related to the bones of the body including:

  • Osteogenic cells
  • Osteoblasts
  • Osteocytes
  • The Haversian Canal
  • Types of Synovial Joints
  • The Human Skeleton

Muscular System

Here you will need to know the three connective tissues (Epimysium, Perimysium, and Endomysium) as well as the muscles of the body. Try to find a HESI A2 practice test anatomy and physiology section that focuses on the face, chest, and leg muscles as those are the most common areas tested.

Cardiovascular System

This section relates to everything in the cardiovascular system including the heart, lungs, and how blood circulates through the body. You will need to know the three layers of heart muscles (Epicardium, Myocardium, and Endocardium) as well as the parts of the heart.

Immune and Lymphatic Systems

When answering these questions on the HESI test, you may find questions relating to cells and parts of the blood, including:

  • T Cells
  • B Cells
  • Thymus
  • Basophil
  • Eosinophil
  • Neutrophil
  • Plasma/Thrombocytes

Endocrine System

Your body secretes hormones to help regulate certain functions of the body, and the endocrine system is to thank for that. In this section of the test, you will need to know big hormones and glands like:

  • Antidiuretic hormone (ADH)
  • Luteinizing hormone (LH)
  • Follicle stimulation hormone (FSH)
  • Prolactin
  • Estrogen
  • Testosterone
  • Aldosterone
  • Oxytocin
  • Serotonin
  • Pituitary gland
  • Pineal gland
  • Adrenal gland
  • Parathyroid gland
  • Hypothalamus

Nervous System

Almost everyone knows your brain controls your body, but the nervous system portion of the test is a much more in-depth look at how the brain does its job. You need to know the difference between sympathetic and parasympathetic systems and parts of the brain, including:

  • Cerebellum
  • Cerebrum
  • Medulla Oblongata
  • Olfactory nerve
  • Optic nerve
  • Vagus nerve
  • Other cranial nerves

Body Senses

You will need to know all the areas associated with the five human senses as well as be able to give detailed descriptions of what is in each body part and how it functions. Look deepest into ears, noses, and eyes to be best prepared for the HESI anatomy and physiology test.

Reproductive System

With the reproductive system, HESI test-takers will need to know all the stages of human and cellular reproduction as well as the organs that reproduce, including:

  • Fertilization
  • Zygotes
  • Estrogen
  • Testosterone
  • Ovaries
  • Fallopian Tubes
  • Prophase
  • Metaphase
  • Anaphase
  • Telophase
  • Cytokinesis

If you still aren’t sure what exactly to study, our next couple of sections will discuss the best methods for studying for the HESI anatomy and physiology exam.

Like all tests you have probably taken in your schooling career, there are plenty of resources to help you study for the HESI A2 exam. Here are some of the top methods we recommend.

Prep Courses

Prep courses are probably the easiest and non-controversial way to study for the HESI A&P exam. A HESI prep course will help you easily learn the material you need to learn as well as practice realistic questions.

Our team reviewed the best HESI prep courses to help you find the options that are available to you.

Flashcards/Online Study

There are a plethora of online resources to help you study and quiz you over topics and questions you may see. Places like Quizlet should have plenty of fun ways to quiz yourself on important topics and create games to help you study best.

If you are finding it difficult to study online or don’t have enough time to pull your computer or phone out to study during breaks, you can always copy their definitions and keywords onto your own paper flashcards for studying on the go.

Practice Test

One of the best ways to study for this portion of the exam is to take a HESI anatomy and physiology practice test. A good HESI anatomy practice test will have plenty of questions covering various topics on the test and will give detailed explanations when you get answers wrong.

If you click the links near the top of this article, you will be led to a HESI anatomy and physiology practice test put together by our experts. They are automatic scoring and will teach you where you need to brush up and where you are doing well.

Does the HESI have anatomy and physiology?

Yes, there are 30 anatomy and physiology questions in that section on the HESI test. Only 25 of those 30 questions are scored.

Can you study for the HESI A&P section?

Yes, in fact, we recommend it. The more you study, the better your chances are of succeeding.

Do practice tests help for the HESI A&P section?

Practice tests can show you where you are lacking in knowledge and help you understand what the questions look like, so they may be one of the most useful study tools for this and any test.